This only happens in this particular file for some reason.
Why is this happening and how do I toggle it off?
It’s the same color profile as my other files.
Very strange behaviour, now I created a new frame and layers and they aren’t consistent with the rest of the file.
I’ve had this as a minor annoyance for ages, found it was only happening on one monitor not the other so put it down to a monitor hardware effect. But changing to sRGB has solved the issue, thank you! 
Hey, it only happens on my external display as well!
Switching to sRGB worked