Animation with variants does not work

Figma prototype does not support relations in the prototype, by relations I mean logical argument or when interacting with a component to affect another.

Although you might see this done a lot, it’s actually happening due to frames changing and smart animate.

In your case there would be no frame changing so it would impossible to do, but there is way to achieve such effect but comes with a compromise.

You might embed the info popup within the component states one where the popup is open with the gray background of the info icon and one where the popup is hidden without background of the info icon. By doing this you won’t be able to position the popup in relation to main parent frame (a.k.a. the page) and you won’t be able to close the popup when clicking outside, which you seam not using anyway.

Thank you for your response! Do you happen to have a link to a good tutorial on this topic?

I have not fount a tutorial specifically for the case you want, but I found you this.

It is a more complex use case, but hey, there’s no harm in knowing more than you need.