How Can we Change layout of the design from LTR to RTL without duplicate designed screen two times?

You will need to show us something more visual. A file or screenshot?

You duplicate the component (as its a variable itself) and swap the form with the image. Call this variable something different.

Surely it’s that easy?

I don’t think there’s an easy way that doesn’t involve having both layouts as either duplicate frames or component variants. The advantage of creating a component of the entire screen in a “RTL” and “LTR” variant is that you can do this for any aspect of the app/site that needs swapping, create a “RTL true/false” variable and then switch all pages back and forth with a single button.

I created a component for each element of this design and also used auto layout so form is a component that has LTR and RTL and Image too, but I am trying to change the layout of the design when we try to change the language. I tried to do it by using the set variable option in the prototype but it did not work.

You will have to duplicate your file and share a link on here please. We can’t imagine all this from your replies, and then try to advise. We need to see something.