A common pain point I run into is when I select a set of frames that are vertically stacked and use auto-layout to quickly change their arrangement to horizontal. This happens often when organizing existing frames into a workflow. This happens to me at least once a week, so it creates not an insignificant amount of friction.
When I set auto-layout for the vertical group, it defaults the individual frames to fill and the outer frame to fixed. When I change the direction of auto-layout to horizontal, it retains the respective fill and fixed selections, thus squishing all the inner frames in the fixed-width layout frame. I then have to undo and manually apply the settings I desire. I think the default setting should be to retain the aspect ratio I’ve already set for the inner frames and set the outer frame to hug. Assume that the inner frames are the size I want them to be and honor that with how auto-layout is applied.