In prototype mode, hold the CTRL/CMD key to enable the Knife tool. Hold the right mouse button and cut through interaction lines to remove connections between frames.
Currently, you can select multiple layers and remove interactions from the context menu, but that removes all interactions (including component states like hover effects, etc). Removing interactions one by one is annoying… With this tool, you can remove interactions between frames without needing to select anything, multiple at once
Blender shader editor has a similar feature for removing connections between nodes, which becomes a must have once you try it. Figma needs this functionality too!