Can I present the Same file in two screens with different resuloution?

Hello,

Basically I have a device, that I’ll extend the screen to an additional huge screen on a small exhibition, the screen size og teh device I’ll be using is 1980x1080, while the other screen is 4200x1344.

The Small Screen I want it to have Buttons that when I press it changes on the big screen, Photo Example:

can it work somehow?